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(NAT REV UROL) 《自然泌尿学评论》

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Published 2012年9月,Volume 9,Issue 9

最新一期

EDITORIAL

Sexual medicine: Let's talk about sex...

Annette Fenner

p473 | doi:10.1038/nrurol.2012.168

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RESEARCH HIGHLIGHTS

Sexual medicine: Experts debate—should DSM-V raise the bar for female sexual dysfunction diagnosis? | PDF (227 KB)

p475 | doi:10.1038/nrurol.2012.171

Sexual medicine: Increased PDE5 levels in a mouse model of type 2 diabetesPDF (103 KB)

p476 | doi:10.1038/nrurol.2012.153

Sexual medicine: Pain and pleasure—reconstruction after female genital mutilation | PDF (47 KB)

p477 | doi:10.1038/nrurol.2012.152

Sexual medicine: Rapid-onset avanafil effective for ED | PDF (47 KB)

p477 | doi:10.1038/nrurol.2012.154

Sexual medicine: PDE5 inhibitor protects testes | PDF (43 KB)

p477 | doi:10.1038/nrurol.2012.170

Sexual medicine: Combined contraceptives—which delivery route is best? |PDF (143 KB)

p478 | doi:10.1038/nrurol.2012.155

Sexual medicine: Can pelvic measurements predict gender identity disorder?PDF (114 KB)

p478 | doi:10.1038/nrurol.2012.159

IN BRIEF

Sexual medicine: Long-acting testosterone injection is well-tolerated and effective | PDF (44 KB)

p476 | doi:10.1038/nrurol.2012.160

Sexual medicine: Fewer infections after antibiotic-impregnated penile prosthesis replacement surgery | PDF (44 KB)

p476 | doi:10.1038/nrurol.2012.161

Sexual medicine: 'Snodgraft' modification for hypospadias repair | PDF (44KB)

p476 | doi:10.1038/nrurol.2012.162

Sexual medicine: Supersensitive fluorescent semen analysis identifies sperm in more samples than conventional analysis | PDF (44 KB)

p476 | doi:10.1038/nrurol.2012.163

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NEWS AND VIEWS

Sexual medicine: The psychological effects of recreational PDE5 inhibitor use

Tamara Melnik

p479 | doi:10.1038/nrurol.2012.149

The availability of PDE5 inhibitors has significantly altered the way in which erectile dysfunction (ED) is treated. Some major issues have emerged since the advent of PDE5 inhibitor use for ED, especially in relation to recreational use in young, healthy men and the role of confidence in erectile ability.

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Sexual medicine: Online risks to health—the problem of counterfeit drugs

Bryan A. Liang & Tim K. Mackey

p480 | doi:10.1038/nrurol.2012.148

Counterfeit medicines sold online are a global scourge. Although erectile dysfunction drugs are well known to be heavily counterfeited, illicit vendors are rapidly expanding to other drugs and devices in the sexual health arena. International multidisciplinary cooperation is needed to address key patient safety concerns resulting from such markets.

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Sexual medicine: When good isn't good enough—treatment for vulvodynia

Ruby H. N. Nguyen

p482 | doi:10.1038/nrurol.2012.145

Finding effective treatment for chronic vulvar pain—vulvodynia—is a challenge. Although two new studies answer critical questions regarding treatment effectiveness for two interventions, both studies found that approximately 40% of women still experience pain during sex (dyspareunia) despite treatment. Is this as good as it gets for these women?

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Sexual medicine: Why stop a good thing? Discontinuing PDE5 inhibitors

Helen M. Conaglen & John V. Conaglen

p483 | doi:10.1038/nrurol.2012.165

Reasons why men discontinue a medication that successfully addresses their erectile dysfunction have been investigated often. A recent study adds few new reasons for discontinuation, but does report which medical conditions result in men discontinuing due to PDE5 inhibitors not being able to restore their erectile function.

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Focus on: Sexual Medicine

Reviews

Sex for fun: a synthesis of human and animal neurobiology

Janniko R. Georgiadis, Morten L. Kringelbach & James G. Pfaus

p486 | doi:10.1038/nrurol.2012.151

Georgiadis et al. provide a comprehensive description of the available animal and human literature on sexual reward and sexual incentive motivation, highlighting the major points of convergence and divergence across species. They discuss a neural concept of human sexual behavioural control and suggest novel testable hypotheses for future sex research.

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Therapeutic strategies for patients with micropenis or penile dysmorphic disorder

Oliver Kayes, Majid Shabbir, David Ralph & Suks Minhas

p499 | doi:10.1038/nrurol.2012.150

In this Review, Kayes and colleagues discuss the aetiology, diagnosis and treatment options for congenital micropenis, acquired micropenis and penile dysmorphic disorder, including both nonsurgical and surgical techniques. They evaluate the role of phalloplasty and penile replacement surgery including transplantation, in this challenging clinical area.

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The hormonal control of ejaculation

Giovanni Corona, Emmanuele A. Jannini, Linda Vignozzi, Giulia Rastrelli & Mario Maggi

p508 | doi:10.1038/nrurol.2012.147

Owing to the expansive nervous components participating in the ejaculation reflex, that multiple neurotransmitters are involved is unsurprising. In this Review, the authors focus on the endocrine control of the ejaculatory reflex and suggest that widely available endocrine therapies might be effective in treating sexual disorders such as premature ejaculation.

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Emerging tools for erectile dysfunction: a role for regenerative medicine

Lukman Hakim, Frank Van der Aa, Trinity J. Bivalacqua, Petter Hedlund & Maarten Albersen

p520 | doi:10.1038/nrurol.2012.143

Men with erectile dysfunction (ED) that is unresponsive to available oral pharmacotherapy with PDE5 inhibitors represent a significant subgroup of patients with the disorder. Such patients might in the near future benefit from regenerative medicine options that restore tissue integrity and signalling in penis-projecting neurons, penile smooth muscle cells and endothelial cells. In this comprehensive Review, the authors discuss the current cutting-edge research in regenerative medicine for ED and consider the therapeutic potential of these techniques for the future.

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Perspectives

OPINION
Challenges in sexual medicine

Selim Cellek & Annamaria Giraldi

p537 | doi:10.1038/nrurol.2012.134

Sexual medicine represents one of the newest medical specialties—indeed it has only recently been recognized as a specialty in its own right. Although research in sexual medicine is at the cutting edge of some of the newest techniques, obstacles remain. Here, Cellek and Giraldi discuss the challenges faced by sexual medicine as a field, including funding difficulties, taboos and female sexual dysfunction.

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