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双胞胎妊娠宜采用羊膜穿刺术还是绒毛膜绒毛取样：哪一项是最佳的取样技术？
Amniocentesis and chorionic villus sampling in twin gestations: which is the best sampling technique?
Simonazzi G, Curti A, Farina A  2010/8/19 14:02:24 
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Am J Obstet Gynecol, 2010,
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Objective:
To compare the fetal loss rate <24weeks and the preterm premature rupture of the membranes <34weeks' gestation according to type of invasive procedure and to sampling techniques in twins.

Study Design:
Retrospective cohort study of 204 twin pregnancies, who underwent amniocentesis (100) or chorionic villus sampling (104).

Results:
Fetal loss rate <4weeks was 3.85% in chorionic villus sampling group and 4.00% in amniocentesis group (P value not significant). According to sampling technique, fetal loss rate was 4.17% (chorionic villus sampling 1 puncture), 2.70% (amniocentesis 1 puncture), 3.75% (chorionic villus sampling 2 punctures), and 4.76% (amniocentesis 2 punctures), (P values not significant). Preterm premature rupture of the membranes rate <34weeks was 8.2% chorionic villus sampling group and 10% in amniocentesis group (P value not significant). According to sampling technique, preterm premature rupture of the membranes rate was 12.5% (chorionic villus sampling 1 puncture), 8.1% (amniocentesis 1 puncture), 6.9% (chorionic villus sampling 2 punctures), and 11.1% (amniocentesis 2 punctures), (P values not significant).

Conclusion:
Double entry technique does not affect significantly the outcomes evaluated, in both amniocentesis and chorionic villus sampling.
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