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关于缺血性卒中后反复指导加强身体活动的效应的ExStroke初步试验:一项多国家参与的随机、对照、临床试验 |
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ExStroke Pilot Trial of the effect of repeated instructions to improve physical activity after ischaemic stroke: A multinational randomised controlled clinical trial |
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Boysen G, Krarup L-H, Zeng X, Oskedra A, Kõrv J, Andersen G, Gluud C, Pedersen A, Lindahl M, Hansen L, Winkel P, Truelsen T 2009/8/26 9:53:00 |
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BMJ, 2009, Volume 339, Issue 7715
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Objectives: To investigate if repeated verbal instructions about physical activity to patients with ischaemic stroke could increase long term physical activity. Design: Multicentre, multinational, randomised clinical trial with masked outcome assessment. Setting: Stroke units in Denmark, China, Poland, and Estonia. Participants: 314 patients with ischaemic stroke aged ≥ 40 years who were able to walk - 157 (mean age 69. 7 years) randomised to the intervention, 157 (mean age 69.4 years) in the control group. Interventions: Patients randomised to the intervention were instructed in a detailed training programme before discharge and at five follow-up visits during 24 months. Control patients had follow-up visits with the same frequency but without instructions in physical activity. Main outcome measures: Physical activity assessed with the Physical Activity Scale for the Elderly (PASE) at each visit. Secondary outcomes were clinical events. Results: The estimated mean PASE scores were 69.1 in the intervention group and 64.0 in the control group (difference 5.0 (95% confidence interval -5.8 to 15.9), P=0.36. The intervention had no significant effect on mortality, recurrent stroke, myocardial infarction, or falls and fractures. Conclusion: Repeated encouragement and verbal instruction in being physically active did not lead to a significant increase in physical activity measured by the PASE score. More intensive strategies seem to be needed to promote physical activity after ischaemic stroke. Trial registration Clinical Trials NCT00132483.
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Correspondence Address: Boysen, G.; Department of Neurology, Bispebjerg Hospital, Copenhagen University Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark; email:gb01@bbh.regionh.dk |
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疾病资源中心
摘自:《西氏内科学》,第23版
患者女性,21岁,因干咳、间歇性气促2个月到急诊科就诊。开始症状为上呼吸道感染引起的鼻塞、流涕和咳嗽。医生检查后开了抗生素。服药后鼻部症状缓解,但仍有轻微干咳和呼吸困难。其他症状包括疲劳和焦虑。否认发热、体重减轻、胸痛、端坐呼吸、气喘、鼻后滴漏、胃灼热以及神经系统症状。
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