中国作者重要发表 - 啮齿类动物皮层内突触传递效率在觉醒时增强、在睡眠时减弱的直接证据



啮齿类动物皮层内突触传递效率在觉醒时增强、在睡眠时减弱的直接证据





Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex





Liu Z-W, Faraguna U, Cirelli C, Tononi G, Gao X-B 2010/7/22 10:33:00

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Journal of Neuroscience, 2010, Volume 30, Issue 25




Despite evidence that waking is associated with net synaptic potentiation and sleep with depression, direct proof for changes in synaptic currents is lacking in large brain areas such as the cerebral cortex. By recording miniature EPSCs (mEPSCs) from frontal cortex slices of mice and rats that had been awake or asleep, we found that the frequency and amplitude of mEPSCs increased after waking and decreased after sleep, independent of time of day. Recovery sleep after deprivation also decreased mEPSCs, suggesting that sleep favors synaptic homeostasis. Since stronger synapses require more energy, space, and supplies, a generalized renormalization of synapses may be an important function of sleep. Copyright © 2010 the authors.



Correspondence Address: Tononi, G.; Department of Psychiatry, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, United States; email:gtononi@wisc.edu



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