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| 儿童注意力缺陷/多动障碍患者的小世界神经功能网络受损 |
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| Altered small-world brain functional networks in children with attention-deficit/hyperactivity disorder |
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| Wang L., Zhu C., He Y., Zang Y., Cao Q., Zhang H., Zhong Q., Wang Y. 2009/5/29 18:40:20 |
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Human Brain Mapping, 2009, Volume 30, Issue 2
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| In this study, we investigated the changes in topological architectures of brain functional networks in attention-deficit/hyperactivity disorder (ADHD). Functional magnetic resonance images (fMRI) were obtained from 19 children with ADHD and 20 healthy controls during resting state. Brain functional networks were constructed by thresholding the correlation matrix between 90 cortical and subcortical regions and further analyzed by applying graph theoretical approaches. Experimental results showed that, although brain networks of both groups exhibited economical small-world topology, altered functional networks were demonstrated in the brain of ADHD when compared with the normal controls. In particular, increased local efficiencies combined with a decreasing tendency in global efficiencies found in ADHD suggested a disorder-related shift of the topology toward regular networks. Additionally, significant alterations in nodal efficiency were also found in ADHD, involving prefrontal, temporal, and occipital cortex regions, which were compatible with previous ADHD studies. The present study provided the first evidence for brain dysfunction in ADHD from the viewpoint of global organization of brain functional networks by using resting-state fMRI. © 2008 Wiley-Liss, Inc. |
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| Correspondence Address: Zhu, C.; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 19 Xinjiekouwai Street, Beijing, China; email: czzhu@bnu.edu.cn |
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 疾病资源中心
摘自：《西氏内科学》，第23版
患者女性，21岁，因干咳、间歇性气促2个月到急诊科就诊。开始症状为上呼吸道感染引起的鼻塞、流涕和咳嗽。医生检查后开了抗生素。服药后鼻部症状缓解，但仍有轻微干咳和呼吸困难。其他症状包括疲劳和焦虑。否认发热、体重减轻、胸痛、端坐呼吸、气喘、鼻后滴漏、胃灼热以及神经系统症状。
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