晚期子宫内膜癌的诊断与治疗标准

Endometrial cancer is the most common gynecological malignancy in the United States and ranks second in gynecologic cancer mortality following only ovarian cancer. More than 84% of patients present with International Federation of Gynecology and Obstetrics (FIGO) stage I–II disease. By definition, patients with advanced stage uterine carcinoma (FIGO stages III–IV) are those with extrauterine disease and are at significant risk of dying from uterine cancer. They constitute a very heterogeneous group of patients with varying risk factors yielding highly variable clinical outcomes. Within the same FIGO stage, patients with disease involving multiple extrauterine sites fare worse compared with patients with involvement of a single site. In a series of patients with FIGO stage IIIC, Mariani et al reported a 5-year relapse-free survival of 68% for patients with only lymph node metastases compared to 25% for patients with lymph node metastases plus peritoneal cytologic, vaginal, uterine serosal or adnexal involvement, or a combination of these

全文地址：