辅助生殖治疗会使后代出生缺陷风险增加吗？

In a recent paper published in the New England Journal of Medicine based on an Australian cohort of 6163 in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) children (1407 after ICSI), Davies et al. (1) conclude that “the risk of birth defects associated with ICSI remained increased after multivariate adjustment, although the possibility of residual confounding cannot be excluded”. This has raised a lot of media attention and concerns among couples treated or pregnant after IVF treatment.

Davies et al. presented an elegant study based on a cohort of assisted reproductive technologies (ART) infants born from 1986 to 2002. However, the study did not refer to a recent Swedish po