AQP8在PCOS女性中的相关性

Association of AQP8 in women with PCOS
作者:Li, Y., Liu, H., Zhao, H., Xu, C., Zhao, Y., Ma, J. , Chen, Z.-J.
机构: 山东大学省立医院生殖医学中心
期刊: REPROD BIOMED ONLINE2013年10月4期27卷

Abstract

Aquaporin 8 (AQP8) has been identified as a novel gene participating in female reproductive physiology. The present study was designed to determine whether an association exists between AQP8 and polycystic ovary syndrome (PCOS). This study recruited 192 women with PCOS and 191 controls. High-resolution melting and sequencing were employed to investigate the genotypes of six single-nucleotide polymorphisms within AQP8 (rs7198838, rs1076973, rs1076974, rs2287797, rs2287798 and rs2287796). A significant difference was found in rs2287798 between PCOS cases and controls (P = 0.0007). Possible associations between AQP8 genotypes and three different phenotypes of this syndrome were investigated. The results support the earlier evidence for a possible role of AQP8 in the pathogenesis of PCOS. Further studies are still needed to elucidate its functional role.

通讯作者:Ma, J.; Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China; email:chenzijiang@vip.163.com
学科代码:妇产科学   关键词:AQP8; Aquaporin; Association s
来源: Scopus
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