阿尔兹海默病可调整风险因素的荟萃分析

Meta-analysis of modifiable risk factors for Alzheimer's disease
2016-02-23 10:15点击:2162次发表评论
作者:Xu, W., Tan, L., Wang, H.-F., Jiang, T., Tan, M.-S., Tan, L., Zhao, Q.-F., Li, J.-Q., Wang, J., Yu, J.-T.
机构: 青岛大学医学院青岛市立医院神经科
期刊: J NEURORADIOLOGY2015年12月12期86卷

Background The aetiology of Alzheimer's disease (AD) is believed to involve environmental exposure and genetic susceptibility. The aim of our present systematic review and meta-analysis was to roundly evaluate the association between AD and its modifiable risk factors. Methods We systematically searched PubMed and the Cochrane Database of Systematic Reviews from inception to July 2014, and the references of retrieved relevant articles. We included prospective cohort studies and retrospective case-control studies. Results 16 906 articles were identified of which 323 with 93 factors met the inclusion criteria for meta-analysis. Among factors with relatively strong evidence (pooled population >5000) in our meta-analysis, we found grade I evidence for 4 medical exposures (oestrogen, statin, antihypertensive medications and non-steroidal antiinflammatory drugs therapy) as well as 4 dietary exposures (folate, vitamin E/C and coffee) as protective factors of AD. We found grade I evidence showing that one biochemical exposure (hyperhomocysteine) and one psychological condition (depression) significantly increase risk of developing AD. We also found grade I evidence indicative of complex roles of pre-existing disease (frailty, carotid atherosclerosis, hypertension, low diastolic blood pressure, type 2 diabetes mellitus (Asian population) increasing risk whereas history of arthritis, heart disease, metabolic syndrome and cancer decreasing risk) and lifestyle (low education, high body mass index (BMI) in mid-life and low BMI increasing the risk whereas cognitive activity, current smoking (Western population), light-to-moderate drinking, stress, high BMI in late-life decreasing the risk) in influencing AD risk. We identified no evidence suggestive of significant association with occupational exposures. Conclusions Effective interventions in diet, medications, biochemical exposures, psychological condition, preexisting disease and lifestyle may decrease new incidence of AD.

通讯机构:Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
学科代码:放射学   关键词:阿尔兹海默病 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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