循环中骨形态生成蛋白7水平升高可预测肺动脉高压患者的死亡

Elevated Levels of Circulating Bone Morphogenetic Protein 7 Predict Mortality in Pulmonary Arterial Hypertension
2016-11-08 16:31发表评论
作者:Liu, D., Wu, B.-X., Sun, N., Yan, Y., Yuan, P., Qu, J.-M., Jing, Z.-C
机构: 同济大学医学院附属上海肺科医院心肺循环科
期刊: CHEST2016年8月2期150卷

Background This study aimed to show whether circulating bone morphogenetic proteins (BMPs) levels are associated with increased risk of mortality in patients with pulmonary arterial hypertension (PAH). Methods A total of 156 patients with PAH including 43 with heritable PAH (HPAH) and 113 with idiopathic PAH (IPAH) diagnosed by gene screening were enrolled in the study. Circulating BMPs were measured by ELISA in plasma samples from patients with HPAH (n = 43) and IPAH (n = 113) and from control subjects (n = 51). Clinical characteristics at baseline and long-term survival were compared according to the different BMP levels. Results Patients with HPAH had significantly higher BMP7 concentrations than patients with IPAH and control subjects (20.1 [interquartile range (IQR), 9.4, 55.2] vs 6.5 [IQR, 3.5, 11.7] and 2.5 [IQR, 0.9, 6.6] pg/mL, respectively; P <001). Elevated plasma BMP7 were associated with a higher risk of mortality after adjustment for sex, 6-minute walk distance, mean right atrial pressure, mean pulmonary arterial pressure, pulmonary vascular resistance, and cardiac output (HR, 1.904; 95% CI, 1.021-3.551; P =043). Patients with IPAH with a BMP7 level > 7.85 pg/mL had a higher risk of mortality than those with a low BMP7 concentration (P =042, log-rank test). Conclusions Levels of circulating BMP7 correlate with mortality in PAH, and may be a predictor of disease in patients with HPAH and IPAH.

© 2016 American College of Chest Physicians

通讯机构:Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China
学科代码:心血管病学 呼吸病学 外科学   关键词:循环中骨形态生成蛋白7水平升高 肺动脉高压 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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