人参总皂苷通过恢复神经递质系统功能障碍而降低大鼠阿尔兹海默症模型中D-半乳糖与A1C13所致的空间记忆障碍

Ginsenosides attenuate D-galactose- and AlCl3-inducedspatial memory impairment by restoring the dysfunction of the neurotransmitter systems in the rat model of Alzheimer's disease
2016-12-30 19:02发表评论
作者:Zhang, Y., Pi, Z. , Song, F., Liu, Z.
机构: 国家长春质谱中心,吉林省中药化学与质谱重点实验室,中国科学院长春应用化学研究所
期刊: J Ethnopharmacol2016年12月24期194卷

Ethnopharmacological relevance Panax ginseng C.A.Mey. is a traditional Chinese herbal medicine, which has been used to treat Alzheimer's disease (AD) for thousands of years. Ginsenoside is one of the major compounds found in P. ginseng. This study aimed to explore the attenuation of spatial memory impairment by ginsenosides and its correlation with restoring the dysfunction of the neurotransmitter systems in AD model rats to understand the mechanism underlying the anti-AD effect of P. ginseng. Materials and methods In this study, the AD model was established by combining D-galactose (D-gal) with AlCl3 (Al) for 60 days. From day 30, the ginsenosides group was intragastrically administered with ginsenosides for 30 days. The ethology of rats was tested through the Morris water maze test(MWM). Histopathological changes in the hippocampus of rats were observed through hematoxylin and eosin staining. The expressions of amyloid β peptide (Aβ) and phospho-tau (p-tau) in the hippocampus and cortex of rats were detected by immunohistochemistry. A liquid chromatography–mass spectrometry assay was used to measure neurotransmitter concentrations in the hippocampus, cortex, and blood. Results Ginsenosides could significantly decrease the escape latency time and the average latency time in the place navigation test and increase the times of crossing the platform area, the percentage of residence time, and the distance in the original platform quadrant in the spatial probe test. Ginsenosides could repair the damage of the hippocampus and reduce the expressions of Aβ and p-tau. Ginsenosides could also increase γ-aminobutyric acid, acetylcholine, and dopamine levels and decrease glutamate and aspartic acid levels in the hippocampus and cortex and increase glycine and serotonin levels in the blood. Conclusions After effectively administrated, ginsenosides attenuate D-gal- and Al-induced spatial memory impairment. The possible mechanism of the beneficial effect is restoring the dysfunction of various neurotransmitters. © 2016 Elsevier Ireland Ltd

通讯机构:National Center for Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
学科代码:内科学 补充和替代医学 药学   关键词:人参总皂苷通 神经递质系统功能障碍 阿尔兹海默症 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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