令人恐惧的音乐可诱发大脑单胺受体的迅速变化：一项初步的PET研究

Tian, M.; Department of Nuclear Medicine, Zhejiang University, School of Medicine, Hangzhou, China; email:meitian@gmail.com

Frightening music can rapidly arouse emotions in listeners that mimic those from actual life-threatening experiences. However, studies of the underlying mechanism for perceiving danger created by music are limited. Methods: We investigated monoamine receptor changes induced by frightening music using 11C-N-methyl-spiperone ( 11C-NMSP) PET. Ten healthy male volunteers were included, and their psychophysiologic changes were evaluated. Results: Compared with the baseline condition, listening to frightening music caused a significant decrease in 11C-NMSP in the right and left caudate nuclei, right limbic region, and right paralimbic region; a particularly significant decrease in the right anterior cingulate cortex; but an increase in the right frontal occipital and left temporal lobes of the cerebral cortex. Conclusion: Transient fright triggers rapid changes in monoamine receptors, which decrease in the limbic and paralimbic regions but increase in the cerebral cortex. Copyright © 2012 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Department of Nuclear Medicine, Zhejiang University, School of Medicine, Hangzhou, China