线粒体动力学：调控机制和在肾脏病理生理中的新角色

Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China

Mitochondria are a class of dynamic organelles that constantly undergo fission and fusion. Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by regulatory proteins. During cell injury or stress, the dynamics is shifted to fission, resulting in mitochondrial fragmentation, which contributes to mitochondrial damage and consequent cell injury and death. Emerging evidence has suggested a role of mitochondrial fragmentation in the pathogenesis of renal diseases including acute kidney injury and diabetic nephropathy. A better understanding of the regulation of mitochondrial dynamics and its pathogenic changes may unveil novel therapeutic strategies. © 2013 International Society of Nephrology.

Dong, Z.; Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China; email:zdong@gru.edu