持续性动脉导管未闭对极低出生体重儿患病率和死亡率的影响

Aim:Because New Caledonia is geographically isolated from the nearest cardiac surgical centre, surgical closure of ductus arteriosus is not performed in very low-birthweight (VLBW) infants who have a persistent patent ductus in spite of having undergone treatment with ibuprofen. This study aimed at investigating the possible effect of persistent patent ductus in VLBW infants.  Methods:The study included 177 VLBW infants born at 25–31weeks of gestation from January 2006 to May 2011. Mortality and major morbidities were compared between infants with a persistent patent ductus (n=33) and those without it (n=104). Statistical associations between potential neonatal risk factors and significant morbidities were identified using multivariate regression analyses.  Results:Rates of mortality and major morbidities, including the rate of bronchopulmonary dysplasia, necrotizing enterocolitis, intraventricular haemorrhage grades I–II and III–IV, periventricular leucomalacia, late-onset infections and failure of hearing screening, were insignificantly higher in VLBW infants with a persistent patent ductus than in those without it.  Conclusion:This study adds further evidence that persistent patent ductus arteriosus has no significant effect on mortality and morbidity in VLBW infants born at ≥25weeks' gestational age.

学科代码：儿科学　　　关键词：持续性动脉导管未闭对极低出生体重儿患病率和死亡率的影响
来源： Eclips