切除壶腹部腺癌患者联合氟尿嘧啶和亚叶酸的辅助化疗、或联合吉西他滨的辅助化疗，与对照观察组相比对存活率的影响：ESPAC -3壶腹周围癌的随机试验

Context  Patients with periampullary adenocarcinomas undergo the same resectional surgery as that of patients with pancreatic ductal adenocarcinoma. Although adjuvant chemotherapy has been shown to have a survival benefit for pancreatic cancer, there have been no randomized trials for periampullary adenocarcinomas.

Objective  To determine whether adjuvant chemotherapy (fluorouracil or gemcitabine) provides improved overall survival following resection.

Design, Setting, and Patients  The European Study Group for Pancreatic Cancer (ESPAC)-3 periampullary trial, an open-label, p