Brain Behavior and Immunity
(BRAIN BEHAV IMMUN) 《大脑、行为和免疫》
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Published 2012年6月,Volume 26,Issue 6
最新一期
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CO2, Ed BoardPage IFC
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Invited Review
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Central nervous system: A modified immune surveillance circuit?Review ArticlePages 823-829 Tania Romo-González, Anahí Chavarría, Jesús Pérez-H
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Full Length Review
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A systematic review of the association between immunogenomic markers and cancer-related fatigueReview ArticlePages 830-848 L.N. Saligan, H.S. Kim
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► This review identified patterns of associations between immunogenomic markers and CRF, and gaps in knowledge needed to advance the science of CRF research.
Named Series: Fatigue, Brain, Behavior, and Immunity
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Stress management skills, neuroimmune processes and fatigue levels in persons with chronic fatigue syndromeReview ArticlePages 849-858 Emily G. Lattie, Michael H. Antoni, Mary Ann Fletcher, Frank Penedo, Sara Czaja, Corina Lopez, Dolores Perdomo, Andreina Sala, Sankaran Nair, Shih Hua Fu, Nancy Klimas
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► The relationship between stress management skills, emotional distress and fatigue in patients with CFS is seen to be most evident in the subgroup that has high levels of IL-6.
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Early life stress and inflammatory mechanisms of fatigue in the Coronary Artery Risk Development in Young Adults (CARDIA) studyReview ArticlePages 859-865 Hyong Jin Cho, Julienne E. Bower, Catarina I. Kiefe, Teresa E. Seeman, Michael R. Irwin
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► Early life stress was longitudinally associated with the development of fatigue but this association was not mediated by low-grade systemic inflammation.
Brief Commentary
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Signal in the NOise: The role of nitric oxide in inflammation anorexiaPage 866 Teresa M. Reyes
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Regular Article
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Lipopolysaccharide inhibits ghrelin-excited neurons of the arcuate nucleus and reduces food intake via central nitric oxide signalingOriginal Research ArticlePages 867-879 Tito Borner, Sarah Pinkernell, Thomas A. Lutz, Thomas Riediger
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► Central inhibition of nitric oxide signaling attenuates disease-related anorexia.
Short Communications
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MyD88 deficiency results in both cognitive and motor impairments in micePages 880-885 J. Drouin-Ouellet, M. LeBel, M. Filali, F. Cicchetti
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► Association of MyD88-dependent pathway to motor and cognitive behavioral impairments.
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CD4+ T cell-mediated neuroprotection is independent of T cell-derived BDNF in a mouse facial nerve axotomy modelPages 886-890 Junping Xin, Nichole A. Mesnard, Taylor Beahrs, Derek A. Wainwright, Craig J. Serpe, Thomas D. Alexander, Virginia M. Sanders, Kathryn J. Jones
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► While CD4+ T cells are a potential source of BDNF after nerve injury, production of BDNF is not necessary for CD4+ T cells to mediate their neuroprotective effects.
Regular Articles
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Heterogeneity of macrophages in injured trigeminal nerves: Cytokine/chemokine expressing vs. phagocytic macrophagesOriginal Research ArticlePages 891-903 SeungHwan Lee, Ji Zhang
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► Macrophages in injured nerves belong to two different immunophenotypes, suggesting immune cells contribute to sensory disturbances under distinctive mechanisms.
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Protective effects of guanosine against sepsis-induced damage in rat brain and cognitive impairmentOriginal Research ArticlePages 904-910 Fabricia Petronilho, Susane Raquel Périco, Francieli Vuolo, Francielle Mina, Larissa Constantino, Clarissa M. Comim, João Quevedo, Diogo Onofre Souza, Felipe Dal-Pizzol
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► Guanosine improve oxidative stress parameters in the brain and recover the memory impairment in CLP-induced sepsis in rats.
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Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjectsOriginal Research ArticlePages 911-918 Sophie Leclercq, Patrice D. Cani, Audrey M. Neyrinck, Peter Stärkel, François Jamar, Moïra Mikolajczak, Nathalie M. Delzenne, Philippe de Timary
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► Our data support a role for a gut–brain interaction in alcohol-dependence and open a new field of research for pharmacological interventions targeting the gut or inflammation.
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Prolongation of prion disease-associated symptomatic phase relates to CD3+ T cell recruitment into the CNS in murine scrapie-infected miceOriginal Research ArticlePages 919-930 Antoine Sacquin, Thomas Chaigneau, Valérie Defaweux, Micheline Adam, Benoit Schneider, Martine Bruley Rosset, Marc Eloit
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► A PrP-derived peptide recruits autoreactive cytolytic CD8+ T cells, which trigger scrapie symptomatic phase extension and CNS T-cell infiltration.
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Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in miceOriginal Research ArticlePages 931-941 Noriaki Kawanishi, Hiromi Yano, Tsubasa Mizokami, Masaki Takahashi, Eri Oyanagi, Katsuhiko Suzuki
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► The present study suggests that exercise training reduced fatty liver, hepatic injury, inflammation, fibrosis, and macrophage infiltration.
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The characterization of a concentration-sensitive α-adrenergic-like octopamine receptor found on insect immune cells and its possible role in mediating stress hormone effects on immune functionOriginal Research ArticlePages 942-950 Jia Huang, Shun-Fan Wu, Xiu-Hua Li, Shelley A. Adamo, Gong-Yin Ye
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► First molecular demonstration of octopamine receptors in an insect immune cell suggests that the neural-immune connections may be conserved from insects to mammals.
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Individually ventilated cages cause chronic low-grade hypoxia impacting mice hematologically and behaviorallyOriginal Research ArticlePages 951-958 Jason M. York, Allison W. McDaniel, Neil A. Blevins, Riley R. Guillet, Sarah O. Allison, Keith A. Cengel, Gregory G. Freund
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► The first work to demonstrate that individually ventilated caging systems create a hypoxic microenvironment that impacts mouse hematology and behavior.
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Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6Original Research ArticlePages 959-971 T.E. Nelson, A. Olde Engberink, R. Hernandez, A. Puro, S. Huitron-Resendiz, C. Hao, P.N.E. De Graan, D.L. Gruol
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► Transgenic mice with chronically elevated levels of IL-6 show enhanced excitatory synaptic transmission in the hippocampus.
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Opioid maintenance therapy restores CD4+ T cell function by normalizing CD4+CD25high regulatory T cell frequencies in heroin userOriginal Research ArticlePages 972-978 Gina-Lucia Riß, Dae-In Chang, Carolin Wevers, Astrid M. Westendorf, Jan Buer, Norbert Scherbaum, Wiebke Hansen
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► Heroin addiction impairs T cell function by expansion of regulatory T cells and this effect can be reversed by opioid maintenance therapy.
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Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activationOriginal Research ArticlePages 979-987 Martina M. Hughes, Angela Carballedo, Declan M. McLoughlin, Francesco Amico, Andrew Harkin, Thomas Frodl, Thomas J. Connor
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► Reduced circulating tryptophan concentrations observed in depressed patients occur independent of IDO induction and kynurenine pathway activation.
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Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: A randomized controlled trialOriginal Research ArticlePages 988-995 Janice K. Kiecolt-Glaser, Martha A. Belury, Rebecca Andridge, William B. Malarkey, Beom Seuk Hwang, Ronald Glaser
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► The data suggest that n-3 PUFAs can reduce inflammation in overweight, sedentary middle-aged and older adults.
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In vivo suppression of plasma IL-12 levels by acute and chronic stress paradigms: Potential mediating mechanisms and sex differencesOriginal Research ArticlePages 996-1005 L. Shaashua, L. Sominsky, B. Levi, L. Sorski, M. Reznick, G.G. Page, S. Ben-Eliyahu
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► Behavioral stressors, surgery, and stress hormones reduce baseline plasma IL-12 levels, novel effects that were not all evident in the induced production approach.
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Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infectionOriginal Research ArticlePages 1006-1016 Heidi A. Jurgens, Rodney W. Johnson
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► Environmental enrichment reduces hippocampal neuroinflammation and helps to preserve cognitive function during peripheral influenza viral infection.
Corrigendum
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Corrigendum to “Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women” [Brain Behav. Immun. 23 (2009) 446–449]Page 1017 Aoife O’Donovan, Jue Lin, Jean Tillie, Firdaus S. Dhabhar, Owen M. Wolkowitz, Elizabeth H. Blackburn, Elissa S. Epel
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