Nature Immunology
(NAT IMMUNOL) 《自然免疫学》

Published 2013年9月,Volume 14,Issue 9



Into the wild: digging at immunology's evolutionary roots pp879 - 883

Rick M Maizels & Daniel H Nussey



News and Views

IFN-β-specific signaling via a unique IFNAR1 interaction pp884 - 885

Surinder Kaur & Leonidas C Platanias


A unique complex of the interferon receptor IFNAR1 and interferon-β (IFN-β) has been identified that signals independently of IFNAR2 and induces a distinct set of interferon-inducible genes and downstream IFN-β-specific functional responses.

See also: Article by de Weerd et al.

Resolving the mystery of pyrophosphate antigen presentation pp886 - 887

Carrie R Willcox, Fiyaz Mohammed & Benjamin E Willcox


Small phosphorylated prenyl metabolites are potent activators of γδ T cells in human peripheral blood, but the molecular mechanism underlying their antigenic potency has remained a mystery. New data identify BTN3A1 as a novel antigen-presentation molecule for both microbial and host-derived phosphorylated antigens.

See also: Article by Vavassori et al.

The danger of sex and death in Scarf1−/− autoimmune mice pp888 - 889

David S Pisetsky


In the absence of the SCARF1 scavenger system in mice, the load of 'dangerous' molecules can increase, inducing features of lupus in a sex-dependent process. These findings highlight the interplay of death and sex in the generation of autoimmunity.

See also: Article by Ramirez-Ortiz et al.

DCs: a dual bridge to protective immunity pp890 - 891

Federica Sallusto


CD11b+ dendritic cells (DCs) represent a subset of classical DCs that require signaling via the receptor Notch2 and lymphotoxin-β receptor and act as obligate source of interleukin 23 for protection against Citrobacter rodentium.

See also: Article by Satpathy et al.


Research Highlights

  • Interferon-induced necroptosis

  • Clustering NK receptors

  • TCRs go it alone

  • Cellular basis of XMEN

  • Regulatory fraction

  • Networks for costimulation



Sterols and oxysterols in immune cell function pp893 - 900

Nathanael J Spann & Christopher K Glass


Sterols and oxysterol derivatives of cholesterol regulate diverse cellular processes. Nathanael Spann and Christopher Glass review the emerging data indicating that these endogenous compounds also serve key roles in almost all aspects of immunological function.



Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1 pp901 - 907

Nicole A de Weerd, Julian P Vivian, Thao K Nguyen, Niamh E Mangan, Jodee A Gould, Susie-Jane Braniff, Leyla Zaker-Tabrizi, Ka Yee Fung, Samuel C Forster, Travis Beddoe, Hugh H Reid, Jamie Rossjohn & Paul J Hertzog


Type I interferons regulate immune responses by signaling via heterodimeric IFNAR1-IFNAR2 complexes. Hertzog and colleagues reveal a unique IFN-β–IFNAR1 signaling complex that is IFNAR2-independent and modulates expression of a distinct set of interferon-inducible genes.

See also: News and Views by Kaur & Platanias

Butyrophilin 3A1 binds phosphorylated antigens and stimulates humanγδ T cells pp908 - 916

Stefano Vavassori, Anil Kumar, Gan Siok Wan, Gundimeda S Ramanjaneyulu, Marco Cavallari, Sary El Daker, Travis Beddoe, Alex Theodossis, Neal K Williams, Emma Gostick, David A Price, Dinish U Soudamini, Kong Kien Voon, Malini Olivo, Jamie Rossjohn, Lucia Mori & Gennaro De Libero


Vγ9Vδ2-expressing cells are a prominent γδ T cell population, but little is known about how they recognize antigens. De Libero and colleagues identify CD277 as an actual antigen-presenting molecule that binds stimulatory phosphorylated antigens.

See also: News and Views by Willcox et al.

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity pp917 - 926

Zaida G Ramirez-Ortiz, William F Pendergraft III, Amit Prasad, Michael H Byrne, Tal Iram, Christopher J Blanchette, Andrew D Luster, Nir Hacohen, Joseph El Khoury & Terry K Means


Failure to clear apoptotic cells can lead to autoinflammatory disease. Means and colleagues demonstrate that the receptor SCARF1 recognizes C1q-bound apoptotic cells, which leads to their clearance and prevents lupus-like symptoms.

See also: News and Views by Pisetsky

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis pp927 - 936

Shuo Yang, Bingwei Wang, Fiachra Humphries, Ruaidhri Jackson, Marc E Healy, Ronan Bergin, Gabriella Aviello, Barry Hall, Deirdre McNamara, Trevor Darby, Aoife Quinlan, Fergus Shanahan, Silvia Melgar, Padraic G Fallon & Paul N Moynagh


The E3 ubiquitin ligases that modify the kinase RIP2 downstream of the receptor Nod2 remain unclear. Moynagh and colleagues show that Pellino3 ubiquitinates RIP2 for Nod2-induced activation of the transcription factor NF-κB.

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens pp937 - 948

Ansuman T Satpathy, Carlos G Briseño, Jacob S Lee, Dennis Ng, Nicholas A Manieri, Wumesh KC, Xiaodi Wu, Stephanie R Thomas, Wan-Ling Lee, Mustafa Turkoz, Keely G McDonald, Matthew M Meredith, Christina Song, Cynthia J Guidos, Rodney D Newberry, Wenjun Ouyang, Theresa L Murphy, Thaddeus S Stappenbeck, Jennifer L Gommerman, Michel C Nussenzweig, Marco Colonna, Raphael Kopan & Kenneth M Murphy


IL-23 is needed to protect mucosal surfaces from bacterial pathogens. Murphy and colleagues identify a Notch-2-dependent CD11b+ dendritic cell population that produces IL-23 and is required for survival after infection with Citrobacter.

See also: News and Views by Sallusto

Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV pp949 - 958

Michael G Overstreet, Alison Gaylo, Bastian R Angermann, Angela Hughson, Young-Min Hyun, Kris Lambert, Mridu Acharya, Alison C Billroth-MacLurg, Alexander F Rosenberg, David J Topham, Hideo Yagita, Minsoo Kim, Adam Lacy-Hulbert, Martin Meier-Schellersheim & Deborah J Fowell


Inflammation induces changes in the extracellular matrix density and composition. Fowell and colleagues show that CD4+ effector T cells use integrin αV for interstitial migration on fibronectin in inflamed tissues.

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells pp959 - 965

Wim Pierson, Bénédicte Cauwe, Antonia Policheni, Susan M Schlenner, Dean Franckaert, Julien Berges, Stephanie Humblet-Baron, Susann Schönefeldt, Marco J Herold, David Hildeman, Andreas Strasser, Philippe Bouillet, Li-Fan Lu, Patrick Matthys, Antonio A Freitas, Rita J Luther, Casey T Weaver, James Dooley, Daniel H D Gray & Adrian Liston


The signals controlling Treg cell homeostasis and survival are still being determined. Liston and colleagues demonstrate that peripheral Treg cells depend critically on IL-2 and the survival factor Mcl-1 but not on Bcl-2.

Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells pp966 - 975

Angelo Castello, Mauro Gaya, Johannes Tucholski, Thomas Oellerich, Kun-Hui Lu, Anna Tafuri, Tony Pawson, Jürgen Wienands, Michael Engelke & Facundo D Batista


The adaptor Nck is known for linking TCR signaling to cytoskeleton regulation. Batista and colleagues show that in B cells, Nck recruits the adaptor BCAP to the BCR to activate the PI(3)K pathway.


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