Nature Immunology
(NAT IMMUNOL) 《自然免疫学》

Into the wild: digging at immunology's evolutionary roots -pp879 - 883

Rick M Maizels & Daniel H Nussey

doi:10.1038/ni.2643

Abstract- Into the wild: digging at immunology's evolutionary roots | Full Text- Into the wild: digging at immunology's evolutionary roots | PDF (526 KB)- Into the wild: digging at immunology's evolutionary roots

IFN-β-specific signaling via a unique IFNAR1 interaction -pp884 - 885

Surinder Kaur & Leonidas C Platanias

doi:10.1038/ni.2686

A unique complex of the interferon receptor IFNAR1 and interferon-β (IFN-β) has been identified that signals independently of IFNAR2 and induces a distinct set of interferon-inducible genes and downstream IFN-β-specific functional responses.

Full Text- IFN-β-specific signaling via a unique IFNAR1 interaction | PDF (663 KB)- IFN-β-specific signaling via a unique IFNAR1 interaction

See also: Article by de Weerd et al.

Resolving the mystery of pyrophosphate antigen presentation -pp886 - 887

Carrie R Willcox, Fiyaz Mohammed & Benjamin E Willcox

doi:10.1038/ni.2689

Small phosphorylated prenyl metabolites are potent activators of γδ T cells in human peripheral blood, but the molecular mechanism underlying their antigenic potency has remained a mystery. New data identify BTN3A1 as a novel antigen-presentation molecule for both microbial and host-derived phosphorylated antigens.

Full Text- Resolving the mystery of pyrophosphate antigen presentation | PDF (261 KB)- Resolving the mystery of pyrophosphate antigen presentation

See also: Article by Vavassori et al.

The danger of sex and death in Scarf1^−/− autoimmune mice -pp888 - 889

David S Pisetsky

doi:10.1038/ni.2684

In the absence of the SCARF1 scavenger system in mice, the load of 'dangerous' molecules can increase, inducing features of lupus in a sex-dependent process. These findings highlight the interplay of death and sex in the generation of autoimmunity.

Full Text- The danger of sex and death in Scarf1−/− autoimmune mice | PDF (607 KB)- The danger of sex and death in Scarf1−/− autoimmune mice

See also: Article by Ramirez-Ortiz et al.

DCs: a dual bridge to protective immunity -pp890 - 891

Federica Sallusto

doi:10.1038/ni.2693

CD11b⁺ dendritic cells (DCs) represent a subset of classical DCs that require signaling via the receptor Notch2 and lymphotoxin-β receptor and act as obligate source of interleukin 23 for protection against Citrobacter rodentium.

Full Text- DCs: a dual bridge to protective immunity | PDF (558 KB)- DCs: a dual bridge to protective immunity

See also: Article by Satpathy et al.

• Interferon-induced necroptosis

• Clustering NK receptors

• TCRs go it alone

• Cellular basis of XMEN

• Regulatory fraction

• Networks for costimulation

Sterols and oxysterols in immune cell function -pp893 - 900

Nathanael J Spann & Christopher K Glass

doi:10.1038/ni.2681

Sterols and oxysterol derivatives of cholesterol regulate diverse cellular processes. Nathanael Spann and Christopher Glass review the emerging data indicating that these endogenous compounds also serve key roles in almost all aspects of immunological function.

Abstract- Sterols and oxysterols in immune cell function | Full Text- Sterols and oxysterols in immune cell function | PDF (896 KB)- Sterols and oxysterols in immune cell function

Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1 -pp901 - 907

Nicole A de Weerd, Julian P Vivian, Thao K Nguyen, Niamh E Mangan, Jodee A Gould, Susie-Jane Braniff, Leyla Zaker-Tabrizi, Ka Yee Fung, Samuel C Forster, Travis Beddoe, Hugh H Reid, Jamie Rossjohn & Paul J Hertzog

doi:10.1038/ni.2667

Type I interferons regulate immune responses by signaling via heterodimeric IFNAR1-IFNAR2 complexes. Hertzog and colleagues reveal a unique IFN-β–IFNAR1 signaling complex that is IFNAR2-independent and modulates expression of a distinct set of interferon-inducible genes.

Abstract- Structural basis of a unique interferon-[beta] signaling axis mediated via the receptor IFNAR1 | Full Text- Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1 | PDF (1,149 KB)- Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1 | Supplementary information

See also: News and Views by Kaur & Platanias

Butyrophilin 3A1 binds phosphorylated antigens and stimulates humanγδ T cells -pp908 - 916

Stefano Vavassori, Anil Kumar, Gan Siok Wan, Gundimeda S Ramanjaneyulu, Marco Cavallari, Sary El Daker, Travis Beddoe, Alex Theodossis, Neal K Williams, Emma Gostick, David A Price, Dinish U Soudamini, Kong Kien Voon, Malini Olivo, Jamie Rossjohn, Lucia Mori & Gennaro De Libero

doi:10.1038/ni.2665

V_γ9V_δ2-expressing cells are a prominent γδ T cell population, but little is known about how they recognize antigens. De Libero and colleagues identify CD277 as an actual antigen-presenting molecule that binds stimulatory phosphorylated antigens.

Abstract- Butyrophilin 3A1 binds phosphorylated antigens and stimulates human [gamma][delta] T cells | Full Text- Butyrophilin 3A1 binds phosphorylated antigens and stimulates humanγδ T cells | PDF (1,505 KB)- Butyrophilin 3A1 binds phosphorylated antigens and stimulates humanγδ T cells | Supplementary information

See also: News and Views by Willcox et al.

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity -pp917 - 926

Zaida G Ramirez-Ortiz, William F Pendergraft III, Amit Prasad, Michael H Byrne, Tal Iram, Christopher J Blanchette, Andrew D Luster, Nir Hacohen, Joseph El Khoury & Terry K Means

doi:10.1038/ni.2670

Failure to clear apoptotic cells can lead to autoinflammatory disease. Means and colleagues demonstrate that the receptor SCARF1 recognizes C1q-bound apoptotic cells, which leads to their clearance and prevents lupus-like symptoms.

Abstract- The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity | Full Text- The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity | PDF (1,511 KB)- The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity | Supplementary information

See also: News and Views by Pisetsky

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis -pp927 - 936

Shuo Yang, Bingwei Wang, Fiachra Humphries, Ruaidhri Jackson, Marc E Healy, Ronan Bergin, Gabriella Aviello, Barry Hall, Deirdre McNamara, Trevor Darby, Aoife Quinlan, Fergus Shanahan, Silvia Melgar, Padraic G Fallon & Paul N Moynagh

doi:10.1038/ni.2669

The E3 ubiquitin ligases that modify the kinase RIP2 downstream of the receptor Nod2 remain unclear. Moynagh and colleagues show that Pellino3 ubiquitinates RIP2 for Nod2-induced activation of the transcription factor NF-κB.

Abstract- Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis | Full Text- Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis | PDF (1,670 KB)- Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis | Supplementary information

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens -pp937 - 948

Ansuman T Satpathy, Carlos G Briseño, Jacob S Lee, Dennis Ng, Nicholas A Manieri, Wumesh KC, Xiaodi Wu, Stephanie R Thomas, Wan-Ling Lee, Mustafa Turkoz, Keely G McDonald, Matthew M Meredith, Christina Song, Cynthia J Guidos, Rodney D Newberry, Wenjun Ouyang, Theresa L Murphy, Thaddeus S Stappenbeck, Jennifer L Gommerman, Michel C Nussenzweig, Marco Colonna, Raphael Kopan & Kenneth M Murphy

doi:10.1038/ni.2679

IL-23 is needed to protect mucosal surfaces from bacterial pathogens. Murphy and colleagues identify a Notch-2-dependent CD11b⁺ dendritic cell population that produces IL-23 and is required for survival after infection with Citrobacter.

Abstract- Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens | Full Text- Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens | PDF (3,636 KB)- Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens | Supplementary information

See also: News and Views by Sallusto

Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin α_V -pp949 - 958

Michael G Overstreet, Alison Gaylo, Bastian R Angermann, Angela Hughson, Young-Min Hyun, Kris Lambert, Mridu Acharya, Alison C Billroth-MacLurg, Alexander F Rosenberg, David J Topham, Hideo Yagita, Minsoo Kim, Adam Lacy-Hulbert, Martin Meier-Schellersheim & Deborah J Fowell

doi:10.1038/ni.2682

Inflammation induces changes in the extracellular matrix density and composition. Fowell and colleagues show that CD4⁺ effector T cells use integrin α_V for interstitial migration on fibronectin in inflamed tissues.

Abstract- Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin [alpha]V | Full Text- Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrinαV | PDF (3,097 KB)- Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrinαV | Supplementary information

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells -pp959 - 965

Wim Pierson, Bénédicte Cauwe, Antonia Policheni, Susan M Schlenner, Dean Franckaert, Julien Berges, Stephanie Humblet-Baron, Susann Schönefeldt, Marco J Herold, David Hildeman, Andreas Strasser, Philippe Bouillet, Li-Fan Lu, Patrick Matthys, Antonio A Freitas, Rita J Luther, Casey T Weaver, James Dooley, Daniel H D Gray & Adrian Liston

doi:10.1038/ni.2649

The signals controlling T_reg cell homeostasis and survival are still being determined. Liston and colleagues demonstrate that peripheral T_reg cells depend critically on IL-2 and the survival factor Mcl-1 but not on Bcl-2.

Abstract- Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells | Full Text- Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells | PDF (1,233 KB)- Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells | Supplementary information

Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells -pp966 - 975

Angelo Castello, Mauro Gaya, Johannes Tucholski, Thomas Oellerich, Kun-Hui Lu, Anna Tafuri, Tony Pawson, Jürgen Wienands, Michael Engelke & Facundo D Batista

doi:10.1038/ni.2685

The adaptor Nck is known for linking TCR signaling to cytoskeleton regulation. Batista and colleagues show that in B cells, Nck recruits the adaptor BCAP to the BCR to activate the PI(3)K pathway.

Abstract- Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells | Full Text- Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells | PDF (2,034 KB)- Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells | Supplementary information