一个多中心队列中的人类免疫缺陷病毒/乙型肝炎病毒共感染患者对联合抗逆转录病毒治疗的免疫学与病毒学应答

Li, T.; Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing Street, Beijing 100730, China; email:litsh@263.net

OBJECTIVE: To evaluate the influence of hepatitis B virus (HBV) coinfection on immunological, virological and clinical responses to lamivudine (3TC)-based combined antiretroviral therapy (cART) in Chinese patients. DESIGN AND METHODS: This prospective, multicenter cohort study recruited 529 antiretroviral-naive participants (aged 18-65 years, both sexes) between 2008 and 2010. They were grouped by HBV serostatus. Virological and immunological responses were monitored at baseline and week 4, 8, 12, 24, 36 and 48. cART for all patients was nevirapine, 3TC with either zidovudine or stavudine. RESULTS: First, HIV/HBV coinfection rate in our cohort was 14.6%. Second, among 508 patients with complete baseline information, median CD4 level was significantly lower in the chronic HBV-infected (CHB) group and isolated core group. In the CHB group, hepatitis B e antigen positivity rather than HBV DNA level was associated with lower CD4 cell count. Third, in the isolated core group, occult infection rate was 9.5%. Fourth, at week 48, rate of HIV suppression below 40copies/ml was 74.2%. Median increase in the CD4 cell count at week 48 was 127cells/μl. Of note, HBV serostatus did not influence virological and immunological response to cART at each follow-up time point. Although HBV serostatus was associated with different alanine aminotransferase levels during follow-up, hepatitis and hyperbilirubinemia rates were not significantly different. Fifth, the 3TC-based regimen was efficacious against HBV replication, with median decrease in HBV DNA of 2.87logcopies/ml. However, hepatitis B e antigen positivity was associated with poorer HBV DNA suppression. CONCLUSION: In our cohort, CHB infection and isolated hepatitis B core antibody positivity were related to faster HIV progression. Despite of this, virological and immunological responses were not affected by HBV serostatus. © 2012 Wolters Kluwer Health | Lippincott Williams &Wilkins.

Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing Street, Beijing 100730, China