经典的和保留神经的根治性子宫切除术:对子宫阔韧带神经损伤的评估
Department of Obstetrics and Gynecology, Nan Fang Hospital of Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou 510515, China
Objectives: This study evaluated histopathology and clinical outcome of autonomic nerve trauma and vessels removal within the cardinal ligament (CL) during nerve-sparing radical hysterectomy (NSRH) compared with radical hysterectomy (RH). Methods: 25 women with FIGO stage Ib1-IIa cervical cancer underwent RH (n = 13) or NSRH (n = 12). Removed CLs lengths were measured. Biopsies were collected from the proximal, middle and distal segment of CLs and fixed. Different markers were used for immunohistochemisty analysis: tyrosine hydroxylase for sympathetic nerves; vasoactive intestinal polypeptide for parasympathetic nerves; CD34 for blood vessels; and D2-40 for lymphatic vessels. The volume density (Vv), a parameter of biological stereology, was used to quantitatively measure CL components, while post-operative functions, such as defecation, micturition and two-year disease free survival in RH and NSRH groups were compared. Results: The nerves mainly existed in the middle and distal segments of CLs. The Vv was greater in RH compared with NSRH for both sympathetic and parasympathetic nerve markers (P < 0.05), while the Vv of blood and lymphatic vessels were same in the two groups. Average time to achieve residual urine ≤ 50 ml and first defecation were shorter in NSRH than in RH (P < 0.05). Conclusions: Less autonomic nerves within CL are transected in NSRH than in RH, while blood/lymphatic vessels are efficiently removed in both treatments. Compared to RH, NSRH decreases iatrogenic injury, which leads to reduced post-operative co-morbidities, with ensure the same radicality. © 2012 Elsevier Inc. All rights reserved.
Liu, P.; Department of Obstetrics and Gynecology, Nan Fang Hospital of Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou 510515, China; email: lpivy@126.com
上一篇: 中国健康男女性的年龄和性别影响身体成分与骨密度之间关系
下一篇: 癌症表观遗传学:从机制到治疗
来源: Scopus
- 您可能感兴趣的文章
-