咖啡、咖啡因摄入量与乳腺癌风险：对37项已发表研究进行的一项新的剂量反应Meta分析

Department of Epidemiology and Health Statistics, Medical College, Qingdao University, Shandong, Qingdao 266021, Dongzhou Road, No. 38, China

Objective We conducted an updated meta-analysis to summarize the evidence from published studies regarding the association of coffee and caffeine intake with breast cancer risk. Methods Pertinent studies were identified by a search of PubMed and by reviewing the reference lists of retrieved articles. The fixed or random effect model was used based on heterogeneity test. The dose-response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression. Results 37 published articles, involving 59,018 breast cancer cases and 966,263 participants, were included in the meta-analysis. No significant association was found between breast cancer risk and coffee (RR = 0.97, P = 0.09), decaffeinated coffee (RR = 0.98, P = 0.55) and caffeine (RR = 0.99, P = 0.73), respectively. And the association was still not significant when combining coffee and caffeine (coffee/caffeine) (RR = 0.97, P = 0.09). However, an inverse association of coffee/caffeine with breast cancer risk was found for postmenopausal women (RR = 0.94, P = 0.02), and a strong and significant association of coffee with breast cancer risk was found for BRCA1 mutation carriers (RR = 0.69, P < 0.01). A linear dose-response relationship was found for breast cancer risk with coffee and caffeine, and the risk of breast cancer decreased by 2% (P = 0.05) for every 2 cups/day increment in coffee intake, and 1% (P = 0.52) for every 200 mg/day increment in caffeine intake, respectively. Conclusions Findings from this meta-analysis suggested that coffee/caffeine might be weakly associated with breast cancer risk for postmenopausal women, and the association for BRCA1 mutation carriers deserves further investigation. © 2013 Elsevier Inc.

Jiang, W.; Department of Epidemiology and Health Statistics, Medical College, Qingdao University, Shandong, Qingdao 266021, Dongzhou Road, No. 38, China;