症状性子宫内膜异位症患者的痛经及其严重程度与子宫收缩力增加和催产素受体(OTR)过表达有关

Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis
作者:Guo, S.-W.a , Mao, X.a, Ma, Q.b, Liu, X.a
机构: 复旦大学附属妇产科医院
期刊: FERTIL STERIL2013年2月1期99卷

Objective: To evaluate uterine contractility, oxytocin receptor (OTR) expression in myometrial smooth muscle cells (MSMCs) derived from uterine tissues from women with and without adenomyosis correlate OTR expression with uterine contractility and dysmenorrhea severity, and see whether trichostatin A (TSA) and andrographolide inhibit OTR expression. Design: Laboratory study using human tissues. Setting: Academic hospital. Patient(s): Twenty patients (cases) with histologically confirmed adenomyosis and 10 (controls) with leiomyomas, cervical dysplasia, and cancer but no adenomyosis or endometriosis. Intervention(s): Dysmenorrhea severity was scored by Visual Analog Scale. Uterine tissue samples were collected during hysterectomy. Myometrial smooth muscle cells derived from tissue samples were cultured and OTR protein levels were measured. The effect of TSA (0.5 or 1 μM) and andrographolide (15 or 30 μM) on OTR expression was evaluated. Main Outcome Measure(s): Visual Analog Scale scores, and contractile amplitude and frequency. The OTR protein levels in MSMCs were quantified by Western blot analysis. Result(s): The contractile amplitude and OTR expression levels were significantly higher in cases than in controls. Dysmenorrhea Visual Analog Scale scores correlated positively with contractile amplitude and OTR expression level. Both TSA and andrographolide dose-dependently inhibit OTR expression in MSMC. Conclusion(s): Oxytocin receptor overexpression in MSMCs may be responsible for increased uterine contractility and adenomyosis-associated dysmenorrhea. Both histone deacetylase inhibitors and andrographolide are therapeutically promising. Copyright © 2013 American Society for Reproductive Medicine, Published by Elsevier Inc.

通讯作者:Guo, S.-W.; Shanghai Obstetrics and Gynecology Hospital, Fudan University, 419 Fangxie Road, Shanghai 200011, China; email:hoxa10@gmail.com
学科代码:妇产科学   关键词:症状性子宫内膜异位
来源: Scopus
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