根据24~28周空腹血糖筛查妊娠糖尿病:来自中国的新证据

Fasting Plasma Glucose at 24-28 Weeks to Screen for Gestational Diabetes Mellitus: New evidence from China
作者:Zhu, W.-W., Fan, L., Yang, H.-X. , Kong, L.-Y., Su, S.-P., Wang, Z.-L., Hu, Y.-L., Zhang, M.-H., Sun, L.-Z., Mi, Y., Du, X.-P., Zhang, H., Wang, Y.-H., Huang, Y.-P., Zhong, L.-R., Wu, H.-R., Li, N., Wang, Y.-F., Kapur, A.
机构: 北京大学第一医院妇产科
期刊: DIABETES CARE2013年7月7期36卷

Abstract

Objective-To evaluate the usefulness of a fasting plasma glucose (FPG) at 24-28 weeks' gestation to screen for gestational diabetes mellitus (GDM). Research design and methods-The medical records and results of a 75-g 2-h oral glucose tolerance test (OGTT) of 24,854 pregnant women without known pre-GDM attending prenatal clinics in 15 hospitals in China were examined. ResultsFPG cutoff value of 5.1 mmol/L identified 3,149 (12.1%) pregnant women with GDM. FPG cutoff value of 4.4 mmol/L ruled out GDM in 15,369 (38.2%) women. With use of this cutoff point, 12.2% of patients with mild GDM will be missed. The positive predictive value is 0.322, and the negative predictive value is 0.928. Conclusions-FPG at 24-28 weeks' gestation could be used as a screening test to identify GDM patients in low-resource regions. Women with an FPG between ≥4.4 and #5.0 mmol/L would require a 75-g OGTT to diagnose GDM. This would help to avoid approximately one-half (50.3%) of the formal 75-g OGTTs in China.

通讯作者:Yang, H.-X.; Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China; email:yanghuixia@bjmu.edu.cn
学科代码:内分泌学与糖尿病   关键词:Gestational Diabetes Mellitus;
来源: Scopus
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