化学减毒寄生虫引发的跨种疟疾免疫

Introduction

Platelet activation and aggregation at sites of vessel wall injury are crucial to prevent posttraumatic blood loss but may also be major participants in diseases such as myocardial infarction and stroke (1, 2). Inhibition of platelet function is an important strategy for prevention and treatment of ischemic diseases (3). Platelet activation results in shape change, functional upregulation of integrin receptors, and the release from dense granules (δ-granules) and α-granules whose contents amplify the activation response and promote thrombus formation and stability. While δ-granules contain small, nonprotein molecules, such as calcium, serotonin, ADP, and ATP, that promote