暴露于多种环境微生物是否会影响过敏和哮喘的发生？

Article Outline

• Abstract
• MAMP exposure and exposure routes
• Microbial environmental diversity and asthma and atopy
• What do we know about microbial diversity in the environment?
• Future challenges
• References
• Copyright

This review describes the recent literature on microbial exposures and protective effects for asthma and atopy. Certain microorganism-associated molecular patterns have been identified as agents that might influence the development of the immune system, which in turn leads to protective effects for asthma and atopy. Endotoxins from gram-negative bacteria were the first agents associated with a reduced risk for asthma and atopy. In later studies, β(1→3)glucans, extracellular polysacchari