转移性乳腺癌的治疗创新：白蛋白纳米技术

In spite of recent advances in the treatment of metastatic breast cancer, this disease remains essentially incurable. Anthracyclines andtaxanes have been widely demonstrated to be the most active cytotoxic drugs for the treatment of breast cancer. Paclitaxel and docetaxelare both hydrophobic drugs that need to be administered with detergent-like substances as solvents. In contrast, nanoparticle albumin-bound(nab) paclitaxel uses the natural characteristics of albumin to reversibly bind paclitaxel, transport it across endothelial cells and concentratethe active ingredient within the tumor. Several trials have demonstrated that nab-paclitaxel results in superior efficacy, with more completeresponses, prolonged time to recurrence and survival, than paclitaxel and docetaxel in MBC. As second-line treatment, the novel formulation has almost doubled overall response rate, increased time to progression and overall survival in comparison with paclitaxel. Due to these results,to date nab-paclitaxel stands out as a promising treatment of metastatic breast cancer.

 

学科代码：肿瘤学 血液病学　　　关键词：转移性乳腺癌 ,全球精选文摘 爱思唯尔医学网, Elseviermed