酵母线粒体硫氧还蛋白氧化促进细胞死亡
Oxidation of the Yeast Mitochondrial Thioredoxin Promotes Cell Death
ABSTRACT
Aims: Yeast, like other eukaryotes, contains a complete mitochondrial thioredoxin system comprising a thioredoxin (Trx3) and a thioredoxin reductase (Trr2). Mitochondria are a main source of reactive oxygen species (ROS) in eukaryotic organisms, and this study investigates the role of Trx3 in regulating cell death during oxidative stress conditions. Results: We have previously shown that the redox state of mitochondrial Trx3 is buffered by the glutathione redox couple such that oxidized mitochondrial Trx3 only accumulates in mutants simultaneously lacking Trr2 and a glutathione reductase (Glr1). We show here that the redox state of mitochondrial T
学科代码:其他 关键词:NONE
来源: Antioxidants & Redox Signaling
来源: Antioxidants & Redox Signaling
顶一下(0)
- 您可能感兴趣的文章
-