Between the Lines of Genetic Code
- 类型：
- 英文原版
- ISBN：
- /
- eISBN：
- 9780123973023
- 出版社：
- Academic Press
- 出版日期：
- 2013-12-13
- 页码：
- 232
- 装帧：
- 电子版
- 价格：
- EUR 108.00
- 购买渠道：
- Elsevier书店
- 中文标题：
- 遗传密码的字里行间
- 作 者：
- Leonid Padyukov
- 中文简介：
-
《遗传密码的字里行间》阐述了衡量和评估基因-基因和基因-环境研究的方法学和工具并展望了未来该学科的前景。本书始于相互作用研究的相关定义，描述了方法学并批判性地评估了当前研究设计的不足和综合性设计的可能性。本书继而提供了最新的应用数据，如风湿性关节炎、多发性硬化、肌炎和其他复杂人体疾病的个案研究。最后，本书考察了患者护理方面当前的研究和未来应用前景。最近的多变量研究显示基因-基因和基因-环境相互作用可解释遗传的显著差异，这在之前的单变量分析中是检测不到的。这些疾病发展过程中基因之间和基因与环境之间的关联可能成为理解病理机制并发展预后、诊断和治疗种种疾病的新工具的重要线索。
- 英文简介：
-
Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care.
Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases.
