Handbook of Epigenetics, 1st Edition
- 类型：
- 英文原版
- ISBN：
- 9780123757098
- eISBN：
- 9780123757104
- 出版社：
- Academic Press
- 出版日期：
- 2010-10-21
- 页码：
- 640
- 装帧：
- 电子版
- 价格：
- EUR 155.00
- 购买渠道：
- Elsevier书店
- 中文标题：
- 实验胚胎学手册，第1版
- 作 者：
- Trygve Tollefsbol
- 中文简介：
-
由于现有很强的证据表明，一些非遗传学因素，如营养、环境和化学暴露对基因表达有影响，因此表观遗传学被很多人看作是“新遗传学”。表观遗传学的影响广泛，包括了组织/器官的再生、X染色体的失活及干细胞的分化、基因组印迹和衰老。表观遗传学的畸变影响了多种疾病，而临床上已经对这些疾病进行了干预，此外，对于肿瘤、免疫疾病、神经疾病和代谢障碍和遗传印记疾病，诸多新型表观遗传学治疗也初现曙光。
在本书中，主要作者撰写了表观遗传学领域的全面的综述，为这一重要且不断发展的主题提供了广阔视野。从分子学机制和表观遗传学技术到人类疾病与临床表观遗传学的诸多发现，从表观遗传学的建立基础到基于表观遗传学的疾病的治疗干预等广泛领域，其学科特征与应用都将在本书中一一展现。 - 英文简介：
-
Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon.
This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders.
