Epigenetics in Human Disease
- 类型：
- 英文原版
- ISBN：
- 9780123884152
- eISBN：
- 9780123884169
- 出版社：
- Academic Press
- 出版日期：
- 2012-09-14
- 页码：
- 592
- 装帧：
- 电子版
- 价格：
- EUR 104.95
- 购买渠道：
- Elsevier书店
- 中文标题：
- 人体疾病实验胚胎学
- 作 者：
- Trygve Tollefsbol
- 中文简介：
-
表观遗传学是发展最为迅速的科学领域之一，它通过考察基因组成解析人类疾病，并承认外界因素在基因表达中起到作用。本卷的目的在于概述我们已具有深入知识的疾病或状况，例如癌症、自身免疫性疾病和老化，以及那些表观遗传学研究方面正在出现突破的，如糖尿病、神经生物学疾病和心血管疾病。无论是在哪个适用领域，人们不仅致力于搞清楚表观遗传学在这些疾病的起源、进展、诊断和预后等方面的作用，同时还探索新的表观遗传学途径来治疗这些疾病。本书的章节中还阐述了人类印迹性疾病、呼吸疾病、感染性疾病和妇产科疾病。由于表观遗传学在老化过程中起到重要作用，表观遗传学在老化方面的进展与和许多人类老化性疾病高度相关。因此，本卷以老化表观遗传学以及现有的通过表观遗传学途径延缓老化的研究突破收尾。本书聚焦于转化应用，适合作为基础科研人员和临床医生的重要参考书。
- 英文简介：
-
Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike.
