硬化蛋白缺失可对B细胞生存带来不良影响

Increased osteoblast activity in sclerostin-knockout (Sost^−/−) mice results in generalized hyperostosis and bones with small bone marrow cavities resulting from hyperactive mineralizing osteoblast populations. Hematopoietic cell fate decisions are dependent on their local microenvironment, which contains osteoblast and stromal cell populations that support both hematopoietic stem cell quiescence and facilitate B-cell development. In this study, we investigated whether high bone mass environments affect B-cell development via the utilization of Sost^−/− mice, a model of sclerosteosis. We found the bone marrow of Sost^−/− mice to be specifically depleted of B cells because of elevated ap