高血压和PI3Kγ：控制血管肌源性紧张度最新治疗目标和目标器官损伤

Abstract

In the past decade, several studies have characterized a number of cellular and molecular mechanisms that contribute to the regulation of the vascular myogenic response, thus affecting blood pressure regulation. Recently, phosphoinositide 3-kinase γ (PI3Kγ) has been identified as a main regulator of vascular myogenic tone and blood pressure, a result further strengthened by a highly significant genome-wide association of a single nucleotide polymorphism flanking this gene with blood pressure regulation, in a large human population. The goal of this review is to summarize the available information regarding the mechanism whereby PI3Kγ exerts blood pressure control, regulating myoge

学科代码：基础医学　　　关键词：Phosphoinositide 3-kinase γ My
来源： Cardiovascular Research