颅内动脉狭窄与轻度认知功能受损进展为阿尔茨海默病

Intracranial artery stenosis and progression from mild cognitive impairment to Alzheimer disease
作者:Zhu, J. | Wang, Y. | Li, J. | Deng, J. | Zhou, H.
机构: 第三军医大学大坪医院神经内科
期刊: NEUROLOGY2014年3月10期82卷

摘要

Objective: To assess the impact of intracranial arterial stenosis on the progression from mild cognitive impairment (MCI) to Alzheimer disease (AD). Methods: A total of 423 participants with MCI were included and evaluated with clinical and neuropsychological examinations annually for 4 years. The incidence of dementia due to AD was investigated. CT angiography was used to measure the stenosis of major intracranial arteries in the studied population. A mixed-effects regression model was used to analyze the association between intracranial arterial stenosis and the progression of MCI, which was assessed with the Mini-Mental State Examination and the Activities of Daily Living scale. Cox proportional hazards models were used to identify the association between intracranial arterial stenosis and dementia progression. Results: At the end of the follow-up, 116 participants had progressed to dementia due to AD, while 223 remained in the MCI stage. Participants with moderate or severe intracranial arterial stenosis had a faster decline in cognition and function relative to participants without such stenosis. The presence of moderate or severe intracranial arterial stenosis significantly increased the risk of dementia progression, even after controlling for age, sex, education, vascular risk factors, and silent MRI lesions. Conclusions: Intracranial arterial stenosis increased the risk of developing AD dementia after MCI. © 2014 American Academy of Neurology.

 

通讯作者:Zhou, H.; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China; 电子邮件:neuro_hdzhou@yahoo.com
学科代码:神经病学   关键词:颅内动脉狭窄;轻度认知功能受损;阿尔茨海默病 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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