非酒精性脂肪肝病中的Kupffer细胞:新观点

Kupffer cells in non-alcoholic fatty liver disease: The emerging view
作者:György Baffy 【全球专家评论】
期刊: J HEPATOL2009年2月1期51卷

Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disorder of our times. Simple steatosis, a seemingly innocent manifestation of NAFLD, may progress into steatohepatitis and cirrhosis, but this process is not well understood. Since NAFLD is associated with obesity and insulin resistance, mechanisms that link lipid metabolism to inflammation offer insights into the pathogenesis. An important parallel between obesity-related pathology of adipose tissue and liver pertains to the emerging role of macrophages and evidence is growing that Kupffer cells critically contribute to progression of NAFLD. Toll-like receptors, in particular TLR4, represent a major conduit for dang


学科代码:消化病学   关键词:非酒精性脂肪肝病中的Kupffer细胞:新观点
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