雷洛昔芬与基于Framingham卒中风险评分的卒中风险
Raloxifene and Risk for Stroke Based on the Framingham Stroke Risk Score
Purpose
Raloxifene reduces vertebral fracture and invasive breast cancer risks, but increases fatal strokes in postmenopausal women at increased coronary risk. We assessed whether this risk is concentrated in postmenopausal women already at high stroke risk.
Methods
Raloxifene Use for The Heart (RUTH) enrolled 10,101 postmenopausal women (mean age 67 years) with or at increased coronary heart disease risk; Multiple Outcomes of Raloxifene Evaluation (MORE) enrolled 7705 osteoporotic postmenopausal women (mean age 66 years). A Framingham Stroke Risk Score (FSRS) was calculated for all women with no prior cerebrovascular events (n=16,858). The validity of the FSRS was assessed in the placebo gro
学科代码：内科学 神经病学 关键词：雷洛昔芬与基于Framingham卒中风险评分的卒中风险
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