自身免疫之历程:自身反应性T细胞如何渗透进入中枢神经系统
An autoimmunity odyssey: how autoreactive T cells infiltrate into the CNS
Abstract
Summary: Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model of multiple sclerosis (MS), a human autoimmune disease. To explore how EAE and ultimately MS is induced, autoantigen-specific T cells were established, were labeled with fluorescent protein by retroviral gene transfer, and were tracked in vivo after adoptive transfer. Intravital imaging with two-photon microscopy was used to record the entire entry process of autoreactive T cells into the CNS: a small number of T cells first appear in the CNS leptomeninges before onset of EAE, and crawl on the intraluminal surface of blood vessels, which is integrin α4 and αL dependent. After extravasation, the
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学科代码:基础医学 关键词:experimental autoimmune enceph autoimmunity T cells two-photon intravital microsco
来源: Immunological Reviews
来源: Immunological Reviews
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