慢性肌酸激酶缺乏最终导致充血性心力衰竭，但其严重程度取决于遗传背景，性别和年龄
Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
Abstract
The creatine kinase (CK) energy transport and buffering system supports cardiac function at times of high demand and is impaired in the failing heart. Mice deficient in muscle- and mitochondrial-CK (M/Mt-CK−/−) have previously been described, but exhibit an unexpectedly mild phenotype of compensated left ventricular (LV) hypertrophy. We hypothesised that heart failure would develop with age and performed echocardiography and LV haemodynamics at 1 year. Since all previous studies have utilised mice with a mixed genetic background, we backcrossed for >10 generations on to C57BL/6, and repeated the in vivo investigations. Male M/Mt-CK−/− mice on the mixed genetic background developed
学科代码：内科学 关键词：Creatine kinase Cardiac energetics Heart failure Energy metabolism Transgenic mice
来源： Basic Research in Cardiology
来源： Basic Research in Cardiology
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