抑制STAT32信号通路可阻止血管平滑肌细胞增殖和新生内膜形成
Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation
Abstract
Dedifferentiation, migration, and proliferation of resident vascular smooth muscle cells (SMCs) are key components of neointima formation after vascular injury. Activation of signal transducer and activator of transcription-3 (STAT3) is suggested to be critically involved in this process, but the complex regulation of STAT3-dependent genes and the functional significance of inhibiting this pathway during the development of vascular proliferative diseases remain elusive. In this study, we demonstrate that STAT3 was activated in neointimal lesions following wire-induced injury in mice. Phosphorylation of STAT3 induced trans-activation of cyclin D1 and survivin in SMCs in vitro and in
学科代码:基础医学 关键词:Smooth muscle cells Neointima Vascular remodeling STAT3 WP1066
来源: Basic Research in Cardiology
来源: Basic Research in Cardiology
顶一下(0)
- 您可能感兴趣的文章
-