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环境微生物暴露多样性是否影响过敏和哮喘的发生?

Does diversity of environmental microbial exposure matter for the occurrence of allergy and asthma?
2012-07-13 16:25点击:11次发表评论
作者:Dick Heederik, PhD, Erika von Mutius, MD, PhD
期刊: J ALLERGY CLIN IMMUN2012年1月1期130卷

Article Outline

  • Abstract
  • MAMP exposure and exposure routes
  • Microbial environmental diversity and asthma and atopy
  • What do we know about microbial diversity in the environment?
  • Future challenges
  • References
  • Copyright

This review describes the recent literature on microbial exposures and protective effects for asthma and atopy. Certain microorganism-associated molecular patterns have been identified as agents that might influence the development of the immune system, which in turn leads to protective effects for asthma and atopy. Endotoxins from gram-negative bacteria were the first agents associated with a reduced risk for asthma and atopy. In later studies, β(1→3)glucans, extracellular polysacchari


学科代码:变态反应、哮喘病与免疫学   关键词:Environmental exposure farming exposure microbial exposure allergy asthma microbiome protective effects
来源: Journal of Allergy and Clinical Immunology
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